#aav-antithrombotic-calculator{--primary:#8637B2;--primary-dark:#6d2a94;--tint:#f3ebfa;--ink:#101123;--ink-soft:#454063;--muted:#6f6a86;--line:#e7e3ef;--line-soft:#f2eff8;--bg:#f6f4fb;--amber:#8a6508;--amber-bg:#fff7e3;--amber-line:#f0dca0;--red:#c0362c;--red-bg:#fdecea;--red-line:#f3c4bf;--green:#17714a;--green-bg:#eaf6f0;--green-line:#bfe3d0;--r-card:14px;--r-field:9px;--r-panel:10px;font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica,Arial,sans-serif;font-size:15px;line-height:1.45;color:var(--ink);background:var(--bg);margin:0;padding:196px 16px 40px}#aav-antithrombotic-calculator *,#aav-antithrombotic-calculator *:before,#aav-antithrombotic-calculator *:after{box-sizing:border-box}#aav-antithrombotic-calculator .aav-content{max-width:1180px;margin:0 auto;container-type:inline-size;container-name:aavwrap}#aav-antithrombotic-calculator a{color:var(--primary-dark)}#aav-antithrombotic-calculator :focus-visible{outline:3px solid var(--primary);outline-offset:1px}#aav-antithrombotic-calculator header.top{display:flex;align-items:center;gap:12px;padding:18px 0 10px}#aav-antithrombotic-calculator .logo{width:44px;height:44px;border-radius:12px;flex:0 0 44px;background:linear-gradient(135deg,var(--primary),#5b1e82);color:#fff;display:flex;align-items:center;justify-content:center;font-weight:800;font-size:20px;letter-spacing:.5px}#aav-antithrombotic-calculator .bname{font-weight:800;font-size:17px;letter-spacing:.2px}#aav-antithrombotic-calculator .bsub{color:var(--muted);font-size:12.5px}#aav-antithrombotic-calculator .btag{margin-left:auto;color:var(--primary-dark);font-weight:700;font-size:12.5px;letter-spacing:.4px;text-transform:uppercase}#aav-antithrombotic-calculator .titleband{padding:6px 0 16px;border-bottom:1px solid var(--line);margin-bottom:18px}#aav-antithrombotic-calculator .titleband h1{font-size:26px;line-height:1.2;margin:0 0 6px;text-wrap:balance}#aav-antithrombotic-calculator .titleband p{margin:0;color:var(--ink-soft);max-width:70ch}#aav-antithrombotic-calculator .audnote{background:var(--tint);border:1px solid var(--line);border-radius:var(--r-panel);padding:10px 14px;margin:0 0 18px;color:var(--ink-soft);font-size:13.5px}#aav-antithrombotic-calculator .modetabs{display:flex;gap:8px;margin:0 0 16px;flex-wrap:wrap}#aav-antithrombotic-calculator .modetabs button{font:inherit;font-weight:700;padding:10px 16px;min-height:44px;border-radius:var(--r-field);border:1.5px solid #8a84a3;background:#fff;color:var(--ink-soft);cursor:pointer}#aav-antithrombotic-calculator .modetabs button[aria-pressed=true]{background:var(--primary);border-color:var(--primary);color:#fff;box-shadow:inset 0 0 0 2px #fff3}#aav-antithrombotic-calculator .modetabs button:focus-visible{outline:3px solid var(--primary-dark);outline-offset:2px}#aav-antithrombotic-calculator main.grid{display:grid;grid-template-columns:1fr 1fr;gap:18px;align-items:start}#aav-antithrombotic-calculator 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.sn{display:inline-flex;width:24px;height:24px;border-radius:6px;background:var(--primary);color:#fff;align-items:center;justify-content:center;font-weight:800;font-size:13px;margin-right:8px;vertical-align:middle}#aav-antithrombotic-calculator .step h3{display:inline;font-size:15.5px;margin:0;vertical-align:middle}#aav-antithrombotic-calculator .step .sx{display:block;color:var(--ink-soft);font-size:13px;margin-top:4px}#aav-antithrombotic-calculator .secbar{border-left:4px solid var(--primary);padding-left:10px;font-weight:800;font-size:16px;margin:0 0 10px}#aav-antithrombotic-calculator .seg{display:flex;gap:8px;flex-wrap:wrap;margin:8px 0 4px}#aav-antithrombotic-calculator .seg button{font:inherit;font-weight:700;min-height:44px;min-width:44px;padding:9px 14px;border-radius:var(--r-field);border:1.5px solid #8a84a3;background:#fff;color:var(--ink-soft);cursor:pointer}#aav-antithrombotic-calculator .seg 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.result{background:linear-gradient(180deg,#101123,#241a3d);color:#fff;border-radius:var(--r-card)}#aav-antithrombotic-calculator .result .rhead{padding:16px 20px 8px;border-bottom:1px solid #ffffff22}#aav-antithrombotic-calculator .result .rhead h2{margin:0;font-size:16px;letter-spacing:.3px;text-transform:uppercase;color:#cbb8e8}#aav-antithrombotic-calculator .result .rbody{padding:14px 20px 20px}#aav-antithrombotic-calculator .bigcard{background:#ffffff10;border:1px solid #ffffff26;border-radius:var(--r-panel);padding:14px 16px;margin:0 0 12px}#aav-antithrombotic-calculator .bignum{font-size:24px;font-weight:800;line-height:1.25;text-wrap:balance}#aav-antithrombotic-calculator .bigsub{color:#cfc6e6;font-size:13.5px;margin-top:6px}#aav-antithrombotic-calculator .metaline{display:flex;gap:14px;flex-wrap:wrap;color:#cfc6e6;font-size:13px;margin:0 0 10px}#aav-antithrombotic-calculator .metaline b{color:#fff}#aav-antithrombotic-calculator .drugcard{background:#ffffff0d;border:1px solid #ffffff22;border-radius:var(--r-panel);padding:12px 14px;margin:0 0 10px}#aav-antithrombotic-calculator .drugcard h4{margin:0 0 2px;font-size:15.5px}#aav-antithrombotic-calculator .drugcard .dclass{color:#cbb8e8;font-size:12px;text-transform:uppercase;letter-spacing:.4px;margin:0 0 8px}#aav-antithrombotic-calculator .working{font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:13.5px;background:#00000042;border-radius:8px;padding:8px 10px;margin:6px 0;overflow-x:auto;white-space:pre-wrap;word-break:break-word}#aav-antithrombotic-calculator .working b{color:#ffd9a8}#aav-antithrombotic-calculator .dmeta{font-size:13px;color:#d9d2ec;margin:6px 0 0}#aav-antithrombotic-calculator .dmeta b{color:#fff}#aav-antithrombotic-calculator .result :focus-visible{outline:3px solid #fff;outline-offset:1px}#aav-antithrombotic-calculator .fpair{display:grid;grid-template-columns:1fr 1fr;gap:0 14px;align-items:start}#aav-antithrombotic-calculator 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.casebar{display:flex;gap:8px;flex-wrap:wrap;margin:0 0 10px}#aav-antithrombotic-calculator .casebar button{font:inherit;font-weight:700;font-size:13px;min-height:40px;padding:6px 12px;border-radius:var(--r-field);border:1.5px solid #8a84a3;background:#fff;color:var(--ink-soft);cursor:pointer}#aav-antithrombotic-calculator .casebar button:hover{background:var(--line-soft)}#aav-antithrombotic-calculator .chips{display:flex;flex-wrap:wrap;gap:6px;margin:8px 0 6px}#aav-antithrombotic-calculator .chip{display:inline-flex;align-items:center;min-height:30px;padding:0 10px;border-radius:999px;font-size:12.5px;font-weight:700;border:1px solid}#aav-antithrombotic-calculator .chip.ok{background:#0f3d29;border-color:#2c7a53;color:#c9f0dc}#aav-antithrombotic-calculator .chip.amber{background:#4a3a08;border-color:#9c8330;color:#ffe9b3}#aav-antithrombotic-calculator .chip.red{background:#5b1712;border-color:#a33a2f;color:#ffd7d0}#aav-antithrombotic-calculator 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.toc{display:flex;flex-wrap:wrap;gap:8px;margin:12px 0 6px;padding:0;list-style:none}#aav-antithrombotic-calculator .toc a{display:inline-flex;align-items:center;background:#fff;border:1px solid var(--line);border-radius:999px;padding:0 16px;min-height:44px;font-size:13px;text-decoration:none;color:var(--primary-dark);font-weight:600}#aav-antithrombotic-calculator details.refsec{background:#fff;border:1px solid var(--line);border-radius:var(--r-panel);margin:0 0 10px}#aav-antithrombotic-calculator details.refsec>summary{cursor:pointer;font-weight:700;padding:12px 36px 12px 14px;list-style:none;position:relative}#aav-antithrombotic-calculator details.refsec>summary::-webkit-details-marker{display:none}#aav-antithrombotic-calculator details.refsec>summary:after{content:"";position:absolute;right:16px;top:50%;width:9px;height:9px;border-right:2.5px solid var(--primary);border-bottom:2.5px solid var(--primary);transform:translateY(-70%) rotate(45deg);transition:transform .15s}#aav-antithrombotic-calculator details.refsec[open]>summary:after{transform:translateY(-30%) rotate(225deg)}#aav-antithrombotic-calculator details.refsec[open]{background:var(--tint)}#aav-antithrombotic-calculator details.refsec .rin{padding:0 14px 14px}#aav-antithrombotic-calculator .tblwrap{overflow-x:auto;border-radius:var(--r-panel);border:1px solid var(--line);background:#fff}#aav-antithrombotic-calculator table.dosetable{border-collapse:collapse;width:100%;font-size:13.5px;min-width:640px}#aav-antithrombotic-calculator table.dosetable th{background:var(--tint);color:var(--primary-dark);text-align:left;padding:10px 12px;border-bottom:2px solid var(--line)}#aav-antithrombotic-calculator table.dosetable td{padding:9px 12px;border-bottom:1px solid var(--line-soft);vertical-align:top;color:var(--ink-soft)}#aav-antithrombotic-calculator table.dosetable td:first-child{font-weight:700;color:var(--ink)}#aav-antithrombotic-calculator .mono{background:#fff;border:1px solid var(--line);border-radius:var(--r-panel);padding:14px 16px;margin:0 0 12px}#aav-antithrombotic-calculator .mono h3{margin:0 0 6px}#aav-antithrombotic-calculator .monolist{margin:8px 0 0;padding-left:18px}#aav-antithrombotic-calculator .monolist li{margin:0 0 5px;font-size:13.5px}#aav-antithrombotic-calculator .howto{padding-left:20px;max-width:75ch}#aav-antithrombotic-calculator .howto li{margin:0 0 8px;color:var(--ink-soft)}#aav-antithrombotic-calculator .glossary{max-width:75ch}#aav-antithrombotic-calculator .glossary dt{font-weight:700;margin:12px 0 2px}#aav-antithrombotic-calculator .glossary dd{margin:0;color:var(--ink-soft)}#aav-antithrombotic-calculator .authorcard{display:flex;gap:14px;background:#fff;border:1px solid var(--line);border-radius:var(--r-card);padding:16px;margin:14px 0}#aav-antithrombotic-calculator .authorcard .av{width:52px;height:52px;border-radius:50%;flex:0 0 52px;background:linear-gradient(135deg,var(--primary),#5b1e82);color:#fff;display:flex;align-items:center;justify-content:center;font-weight:800;font-size:19px}#aav-antithrombotic-calculator .refs li{font-size:13px;margin:0 0 6px}#aav-antithrombotic-calculator footer.foot{margin-top:30px;padding-top:14px;border-top:1px solid var(--line);color:var(--muted);font-size:12.5px}#aav-pinbar{position:fixed;left:0;right:0;bottom:0;z-index:60;display:none;background:#101123;color:#fff;padding:10px 14px calc(10px + env(safe-area-inset-bottom));box-shadow:0 -4px 18px #0006;font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica,Arial,sans-serif;font-size:13.5px}#aav-pinbar .pb-line{display:flex;align-items:center;gap:10px;max-width:640px;margin:0 auto}#aav-pinbar .pb-main{flex:1;min-width:0}#aav-pinbar .pb-l1,#aav-pinbar .pb-l2{display:block;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}#aav-pinbar .pb-l2{font-size:12.5px;color:#d9d2ec;margin-top:2px}#aav-pinbar .pb-main b{color:#e8dcff}#aav-pinbar .pb-jump{font:inherit;font-weight:700;background:#8637b2;border:none;color:#fff;border-radius:9px;min-height:44px;padding:10px 12px;cursor:pointer;flex:0 0 auto}#aav-pinbar.alert{background:#5b1712}#aav-pinbar.alert .pb-jump{background:#c0362c}#aav-pinbar.caution{background:#4a3a08}#aav-pinbar:focus-visible,#aav-pinbar .pb-jump:focus-visible{outline:3px solid #fff;outline-offset:1px}@media(max-width:900px){#aav-pinbar{display:block}#aav-antithrombotic-calculator.aav-pinpad{padding-bottom:76px}}@media(max-width:600px){#aav-pinbar{padding:8px 12px calc(8px + env(safe-area-inset-bottom));font-size:13px}#aav-pinbar .pb-jump{min-height:44px;padding:8px 12px}#aav-antithrombotic-calculator .seg{gap:8px}#aav-antithrombotic-calculator .seg button{min-height:48px;padding:10px 14px;flex:1 1 auto}#aav-antithrombotic-calculator .modetabs{gap:6px}#aav-antithrombotic-calculator .modetabs button{min-height:48px;flex:1 1 0;padding:10px 6px;font-size:14px;white-space:nowrap}#aav-antithrombotic-calculator .ckrow{padding:9px 6px}}#aav-antithrombotic-calculator .jumpres{display:none;margin:0 0 12px}@container aavwrap (max-width:900px){#aav-antithrombotic-calculator .jumpres{display:block}}@media(max-width:900px){#aav-antithrombotic-calculator .jumpres{display:none}}#aav-antithrombotic-calculator .jumpres a{display:inline-block;background:var(--primary);color:#fff;font-weight:700;border-radius:var(--r-field);padding:10px 16px;text-decoration:none}#aav-antithrombotic-calculator .sr-only,#aav-printsheet .sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0 0 0 0);white-space:nowrap;border:0}#aav-antithrombotic-calculator .skip{position:absolute;left:-9999px;top:0;background:#fff;color:var(--primary-dark);font-weight:700;padding:10px 14px;border-radius:0 0 9px;z-index:70}#aav-antithrombotic-calculator .skip:focus{left:0}#aav-printsheet{display:none}@media print{body{background:#fff!important}#aav-antithrombotic-calculator,#aav-pinbar{display:none!important}#aav-printsheet{display:block;font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica,Arial,sans-serif;color:#111;font-size:12.5px;line-height:1.45;-webkit-print-color-adjust:exact;print-color-adjust:exact}#aav-printsheet h1{font-size:19px;margin:0 0 2px}#aav-printsheet .ph-sub{color:#555;margin:0 0 12px;font-size:11.5px}#aav-printsheet .ps-box{border:1.2px solid #999;border-radius:8px;padding:10px 12px;margin:0 0 10px;page-break-inside:avoid}#aav-printsheet .ps-box h2{font-size:13.5px;margin:0 0 6px;text-transform:uppercase;letter-spacing:.4px}#aav-printsheet .ps-warn{border-left:4px solid #b00;padding-left:8px;margin:0 0 6px}#aav-printsheet .ps-warn.amber{border-left-color:#b8860b}#aav-printsheet .ps-warn.info{border-left-color:#666}#aav-printsheet .ps-work{font-family:ui-monospace,Menlo,Consolas,monospace;font-size:11.5px;margin:2px 0}#aav-printsheet 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